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Elongation factor P is required to maintain proteome homeostasis at high growth rate
Elongation factor P (EF-P) is a universally conserved translation factor that alleviates ribosome pausing at polyproline (PPX) motifs by facilitating peptide bond formation. In the absence of EF-P, PPX peptide bond formation can limit translation rate, leading to pleotropic phenotypes including slow...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6205485/ https://ncbi.nlm.nih.gov/pubmed/30297417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812025115 |
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