Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy

Centronuclear myopathies (CNM) are a group of severe muscle diseases for which no effective therapy is currently available. We have previously shown that reduction of the large GTPase DNM2 in a mouse model of the X-linked form, due to loss of myotubularin phosphatase MTM1, prevents the development o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Buono, Suzie, Ross, Jacob A., Tasfaout, Hichem, Levy, Yotam, Kretz, Christine, Tayefeh, Leighla, Matson, John, Guo, Shuling, Kessler, Pascal, Monia, Brett P., Bitoun, Marc, Ochala, Julien, Laporte, Jocelyn, Cowling, Belinda S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205463/
https://ncbi.nlm.nih.gov/pubmed/30291191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808170115
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