p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

Autism spectrum disorder (ASD) is a common neurobehavioral disorder with limited treatment options. Activation of p38 MAPK signaling networks has been identified in ASD, and p38 MAPK signaling elevates serotonin (5-HT) transporter (SERT) activity, effects mimicked by multiple, hyperfunctional SERT c...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Robson, Matthew J., Quinlan, Meagan A., Margolis, Kara Gross, Gajewski-Kurdziel, Paula A., Veenstra-VanderWeele, Jeremy, Gershon, Michael D., Watterson, D. Martin, Blakely, Randy D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205438/
https://ncbi.nlm.nih.gov/pubmed/30297392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809137115
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