O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis

Mutant KRAS drives glycolytic flux in lung cancer, potentially impacting aberrant protein glycosylation. Recent evidence suggests aberrant KRAS drives flux of glucose into the hexosamine biosynthetic pathway (HBP). HBP is required for various glycosylation processes, such as protein N- or O-glycosyl...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Taparra, Kekoa, Wang, Hailun, Malek, Reem, Lafargue, Audrey, Barbhuiya, Mustafa A., Wang, Xing, Simons, Brian W., Ballew, Matthew, Nugent, Katriana, Groves, Jennifer, Williams, Russell D., Shiraishi, Takumi, Verdone, James, Yildirir, Gokben, Henry, Roger, Zhang, Bin, Wong, John, Wang, Ken Kang-Hsin, Nelkin, Barry D., Pienta, Kenneth J., Felsher, Dean, Zachara, Natasha E., Tran, Phuoc T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205381/
https://ncbi.nlm.nih.gov/pubmed/30130254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94844
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