miR-125a Promotes the Progression of Giant Cell Tumors of Bone by Stimulating IL-17A and β-Catenin Expression

Giant cell tumors of bone (GCTBs) exhibit high recurrence and aggressive bone lytic behavior; but, the mechanism of GCTB progression is largely unknown. In GCTB, we detected abundant levels of miR-125a, which were associated with tumor extension, grade, and recurrence. miR-125a stimulates stromal ce...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Jin, Hua, Li, Dian-Wei, Wang, Shu-Nan, Luo, Song, Li, Qing, Huang, Ping, Wang, Jian-Min, Xu, Meng, Xu, Cheng-Xiong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205328/
https://ncbi.nlm.nih.gov/pubmed/30388623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.09.021
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