Phosphorylated Hsp27 is mutually exclusive with ATRX loss and the IDH1(R132H) mutation and may predict better prognosis among glioblastomas without the IDH1 mutation and ATRX loss

AIM: To identify biomarkers for accurate classification of glioma. PATIENTS AND METHODS: We evaluated the heat shock protein 27 (Hsp27), phosphorylated Hsp27 (p-Hsp27), ATRX and IDH1(R132H)proteins using immunohistochemistry in 421 glioma tissues. The χ(2) test was used to assess the relationship be...

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Détails bibliographiques
Publié dans:J Clin Pathol
Auteurs principaux: Cai, Hong-Qing, Wang, Peng-Fei, Zhang, Hai-Peng, Cheng, Zhi-Jian, Li, Shou-Wei, He, Jie, Zhang, Yu, Hao, Jia-Jie, Wang, Ming-Rong, Yan, Chang-Xiang, Wan, Jing-Hai
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2018
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204978/
https://ncbi.nlm.nih.gov/pubmed/29550762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jclinpath-2018-205000
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