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Molecular mechanism of the synergistic activity of ethambutol and isoniazid against Mycobacterium tuberculosis

Isoniazid (INH) and ethambutol (EMB) are two major first-line drugs for managing tuberculosis (TB), caused by the microbe Mycobacterium tuberculosis. Although co-use of these two drugs is common in clinical practice, the mechanism for the potential synergistic interplay between them remains unclear....

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Publicat a:J Biol Chem
Autors principals: Zhu, Chen, Liu, Yu, Hu, Lihua, Yang, Min, He, Zheng-Guo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204910/
https://ncbi.nlm.nih.gov/pubmed/30185616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002693
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