Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry

Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) designed for the treatment of HER2-positive cancers. T-DM1 is composed of the humanized monoclonal antibody trastuzumab connected to a maytansine derivative cytotoxic drug, via a nonreducible thioether linker at random lysine residues...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:MAbs
Asıl Yazarlar: He, Jintang, Yu, Shang-Fan, Yee, Sharon, Kaur, Surinder, Xu, Keyang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2018
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204834/
https://ncbi.nlm.nih.gov/pubmed/29958059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1494487
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