Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection

Developing an effective and safe recombinant vaccine requires microbe-specific antigens combined with an adjuvant/delivery system to strengthen protective immunity. In this study, we designed and expressed a multivalent recombinant Coccidioides polypeptide antigen (rCpa1) that consists of three prev...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Hung, Chiung-Yu, Zhang, Hao, Castro-Lopez, Natalia, Ostroff, Gary R., Khoshlenar, Payam, Abraham, Ambily, Cole, Garry T., Negron, Austin, Forsthuber, Thomas, Peng, Tao, Galgiani, John N., Ampel, Neil M., Yu, Jieh-Juen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204714/
https://ncbi.nlm.nih.gov/pubmed/30104216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00070-18
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