Angiotensin‐converting enzyme 2 deficiency accelerates and angiotensin 1‐7 restores age‐related muscle weakness in mice

BACKGROUND: A pharmacologic strategy for age‐related muscle weakness is desired to improve mortality and disability in the elderly. Angiotensin‐converting enzyme 2 (ACE2) cleaves angiotensin II into angiotensin 1‐7, a peptide known to protect against acute and chronic skeletal muscle injury in roden...

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Publié dans:J Cachexia Sarcopenia Muscle
Auteurs principaux: Takeshita, Hikari, Yamamoto, Koichi, Nozato, Satoko, Takeda, Masao, Fukada, So‐ichiro, Inagaki, Tadakatsu, Tsuchimochi, Hirotsugu, Shirai, Mikiyasu, Nozato, Yoichi, Fujimoto, Taku, Imaizumi, Yuki, Yokoyama, Serina, Nagasawa, Motonori, Hamano, Go, Hongyo, Kazuhiro, Kawai, Tatsuo, Hanasaki‐Yamamoto, Hiroko, Takeda, Shuko, Takahashi, Toshimasa, Akasaka, Hiroshi, Itoh, Norihisa, Takami, Yoichi, Takeya, Yasushi, Sugimoto, Ken, Nakagami, Hironori, Rakugi, Hiromi
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
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Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204583/
https://ncbi.nlm.nih.gov/pubmed/30207087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12334
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