First line chemotherapy responsiveness and patterns of metastatic spread identify clinical syndromes present within advanced KRAS mutant non-small cell lung cancer with different prognostic significance

PURPOSE: Unsuccessful KRAS-specific treatment approaches in non-small cell lung cancer (NSCLC) may reflect underlying disease heterogeneity. We sought to define clinical ‘syndromes’ within advanced KRAS mutant NSCLC to improve future clinical trials and create a clinical framework for future molecul...

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Vydáno v:Clin Lung Cancer
Hlavní autoři: Iams, Wade T., Yu, Hui, Shyr, Yu, Patil, Tejas, Horn, Leora, McCoach, Caroline, Kelly, Karen, Doebele, Robert C., Camidge, D. Ross
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204301/
https://ncbi.nlm.nih.gov/pubmed/30197261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cllc.2018.08.011
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