Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...

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Pubblicato in:Commun Biol
Autori principali: Cheng, Chun-Ting, Qi, Yue, Wang, Yi-Chang, Chi, Kevin K., Chung, Yiyin, Ouyang, Ching, Chen, Yun-Ru, Oh, Myung Eun, Sheng, Xiangpeng, Tang, Yulong, Liu, Yun-Ru, Lin, H. Helen, Kuo, Ching-Ying, Schones, Dustin, Vidal, Christina M., Chu, Jenny C.-Y., Wang, Hung-Jung, Chen, Yu-Han, Miller, Kyle M., Chu, Peiguo, Yen, Yun, Jiang, Lei, Kung, Hsing-Jien, Ann, David K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203837/
https://ncbi.nlm.nih.gov/pubmed/30393775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0178-4
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