The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes

There is growing focus on mitochondrial impairment and cardiovascular diseases (CVD) in type 2 diabetes (T2D), and the development of novel therapeutic strategies in this context. It is unknown whether mitochondrial-targeting antioxidants such as SS-31 protect sufficiently against oxidative damage i...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Escribano-Lopez, Irene, Diaz-Morales, Noelia, Iannantuoni, Francesca, Lopez-Domenech, Sandra, de Marañon, Aranzazu M, Abad-Jimenez, Zaida, Bañuls, Celia, Rovira-Llopis, Susana, Herance, Jose R, Rocha, Milagros, Victor, Victor M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203778/
https://ncbi.nlm.nih.gov/pubmed/30367115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34251-8
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