Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

The conversion of serine and glycine that is accomplished by serine hydroxymethyltransferase 2 (SHMT2) in mitochondria is significantly upregulated in various cancers to support cancer cell proliferation. In this study, we observed that SHMT2 is acetylated at K95 in colorectal cancer (CRC) cells. SI...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Wei, Zhen, Song, Jinglue, Wang, Guanghui, Cui, Ximao, Zheng, Jun, Tang, Yunlan, Chen, Xinyuan, Li, Jixi, Cui, Long, Liu, Chen-Ying, Yu, Wei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203763/
https://ncbi.nlm.nih.gov/pubmed/30367038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06812-y
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