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Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically-Photosensitive Retinal Ganglion Cells
Non-image-forming vision in mammals is mediated primarily by melanopsin-expressing, intrinsically-photosensitive retinal ganglion cells (ipRGCs). In mouse M1-ipRGCs, by far the best-studied subtype, melanopsin activates PLCβ4 (phospholipase C-β4) to open TRPC6,7 channels, mechanistically similar to...
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| Gepubliceerd in: | Cell |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6203304/ https://ncbi.nlm.nih.gov/pubmed/30270038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.055 |
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