The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ

BACKGROUND: Metabolic reprogramming occurs in the tumor microenvironment and influences the survival and function of tumor and immune cells. Interferon-γ (IFN-γ) produced by T cells up-regulates PD-L1 expression in tumors. However, reports regarding the relationship between nutrient metabolism and t...

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Bibliographische Detailangaben
Veröffentlicht in:Onco Targets Ther
Hauptverfasser: Wang, Liping, Yang, Xuecheng, Li, Dan, Liang, Zhijuan, Chen, Yuanbin, Ma, Guofeng, Wang, Yonghua, Li, Yongxin, Liang, Ye, Niu, Haitao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203092/
https://ncbi.nlm.nih.gov/pubmed/30425515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S180505
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