Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether–lumefantrine and artesunate–amodiaquine in Africa

Artemether–lumefantrine (AL) and artesunate–amodiaquine (AS-AQ) are the most commonly used artemisinin-based combination therapies (ACT) for treatment of Plasmodium falciparum in Africa. Both treatments remain efficacious, but single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multi...

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Vydáno v:BMJ Glob Health
Hlavní autoři: Okell, Lucy C, Reiter, Lisa Malene, Ebbe, Lene Sandø, Baraka, Vito, Bisanzio, Donal, Watson, Oliver J, Bennett, Adam, Verity, Robert, Gething, Peter, Roper, Cally, Alifrangis, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202998/
https://ncbi.nlm.nih.gov/pubmed/30397515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjgh-2018-000999
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