Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function

Acute myeloid leukemia (AML) can evade the mouse and human innate immune system by suppressing natural killer (NK) cell development and NK cell function. This is driven in part by the overexpression of microRNA (miR)–29b in the NK cells of AML patients, but how this occurs is unknown. In the current...

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Udgivet i:Blood
Main Authors: Scoville, Steven D., Nalin, Ansel P., Chen, Luxi, Chen, Li, Zhang, Michael H., McConnell, Kathleen, Beceiro Casas, Susana, Ernst, Gabrielle, Traboulsi, Abd Al-Rahman, Hashi, Naima, Williams, Monica, Zhang, Xiaoli, Hughes, Tiffany, Mishra, Anjali, Benson, Don M., Saultz, Jennifer N., Yu, Jianhua, Freud, Aharon G., Caligiuri, Michael A., Mundy-Bosse, Bethany L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Immunobiology and Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202909/
https://ncbi.nlm.nih.gov/pubmed/30158248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-838474
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