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Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D

Upregulations of neuronal nitric oxide synthase (nNOS) in the rodent brain have been associated with neuronal aging. To address underlying mechanisms we generated SH-SY5Y neuronal cells constitutively expressing nNOS at a level similar to mouse brain (nNOS+ versus MOCK). Initial experiments revealed...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Valek, Lucie, Heidler, Juliana, Scheving, Reynir, Wittig, Ilka, Tegeder, Irmgard
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202877/
https://ncbi.nlm.nih.gov/pubmed/30368041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.10.002
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