RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing

The highly intronic nature of protein coding genes in mammals necessitates a co-transcriptional splicing mechanism as revealed by mNET-seq analysis. Immunoprecipitation of MNase-digested chromatin with antibodies against RNA polymerase II (Pol II) shows that active spliceosomes (both snRNA and prote...

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Vydáno v:Mol Cell
Hlavní autoři: Nojima, Takayuki, Rebelo, Kenny, Gomes, Tomás, Grosso, Ana Rita, Proudfoot, Nicholas J., Carmo-Fonseca, Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201815/
https://ncbi.nlm.nih.gov/pubmed/30340024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.09.004
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