Effects of interleukin‐17A in nucleus pulposus cells and its small‐molecule inhibitors for intervertebral disc disease

Intervertebral discs (IVD) degeneration, which is caused by ageing or mechanical stress, leads to IVD disease, including back pain and sciatica. The cytokine interleukin (IL)‐17A is elevated in NP cells during IVD disease. Here we explored the pharmacotherapeutic potential of IL‐17A for the treatmen...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Suyama, Kaori, Sakai, Daisuke, Hirayama, Noriaki, Nakamura, Yoshihiko, Matsushita, Erika, Terayama, Hayato, Qu, Ning, Tanaka, Osamu, Sakabe, Kou, Watanabe, Masahiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201370/
https://ncbi.nlm.nih.gov/pubmed/30207057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13828
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