A Phase 1 Study of Dasatinib plus All-Trans Retinoic Acid in Acute Myeloid Leukemia

Src family kinases (SFKs) are hyperactivated in acute myeloid leukemia (AML). SFKs impede the retinoic acid receptor, and SFK inhibitors enhance all-trans retinoic acid (ATRA)-mediated cellular differentiation in AML cell lines and primary blasts. To translate these findings into the clinic, we unde...

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Pubblicato in:Leuk Lymphoma
Autori principali: Redner, Robert L., Beumer, Jan H., Kropf, Patricia, Agha, Mounzer, Boyiadzis, Michael, Dorritie, Kathleen, Farah, Rafic, Hou, Jing-Zhao, Im, Annie, Lim, Seah H., Raptis, Anastasios, Sehgal, Alison, Christner, Susan M., Normolle, Daniel, Johnson, Daniel E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201295/
https://ncbi.nlm.nih.gov/pubmed/29616864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2018.1443330
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