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Aptamer-enabled uptake of small molecule ligands

The relative ease of isolating aptamers with high specificity for target molecules suggests that molecular recognition may be common in the folds of natural RNAs. We show here that, when expressed in cells, aptamers can increase the intracellular concentrations of their small molecule ligands. We ha...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Auwardt, Supipi Liyamali, Seo, Yeon-Jung, Ilgu, Muslum, Ray, Judhajeet, Feldges, Robert R., Shubham, Shambhavi, Bendickson, Lee, Levine, Howard A., Nilsen-Hamilton, Marit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200808/
https://ncbi.nlm.nih.gov/pubmed/30356136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33887-w
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