Structure-function analyses of the N-butanoyl L-homoserine lactone quorum-sensing signal define features critical to activity in RhlR

Pseudomonas aeruginosa is an opportunistic pathogen that coordinates the production of many virulence phenotypes at high population density via quorum sensing (QS). The LuxR-type receptor RhlR plays an important role in the P. aeruginosa QS process, and there is considerable interest in the developm...

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Publicado no:ACS Chem Biol
Main Authors: Boursier, Michelle E., Moore, Joseph D., Heitman, Katherine M., Shepardson-Fungairino, Sally P., Combs, Joshua B., Koenig, Lea C., Shin, Daniel, Brown, Eric C., Nagarajan, Rajesh, Blackwell, Helen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200399/
https://ncbi.nlm.nih.gov/pubmed/30114353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00577
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