Comparison of Aerosol- and Percutaneous-acquired Venezuelan Equine Encephalitis in Humans and Nonhuman Primates for Suitability in Predicting Clinical Efficacy under the Animal Rule

Licensure of medical countermeasure vaccines to protect against aerosolized Venezuelan equine encephalitis virus (VEEV) requires the use of the Animal Rule to assess vaccine efficacy, because human studies are not feasible or ethical. We therefore performed a retrospective study of VEE cases that oc...

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Vydáno v:Comp Med
Hlavní autoři: Rusnak, Janice M, Dupuy, Lesley C, Niemuth, Nancy A, Glenn, Andrew M, Ward, Lucy A
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for Laboratory Animal Science 2018
Témata:
Nonhuman Primate Models
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200028/
https://ncbi.nlm.nih.gov/pubmed/30282570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.30802/AALAS-CM-18-000027
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