Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

BACKGROUND: Polyriboinosinic-polyribocytidylic acid (polyI:C) triggers a strong innate immune response that mimics immune activation by viral infections. Induction of interferon-induced transmembrane protein 3 (Ifitm3) in astrocytes has a crucial role in polyI:C-induced neurodevelopmental abnormalit...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Yamada, Shinnosuke, Itoh, Norimichi, Nagai, Taku, Nakai, Tsuyoshi, Ibi, Daisuke, Nakajima, Akira, Nabeshima, Toshitaka, Yamada, Kiyofumi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198367/
https://ncbi.nlm.nih.gov/pubmed/30348171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1332-0
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