Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells

β-cell proliferation induction is a promising therapeutic strategy to restore β-cell mass. By screening small molecules in a transgenic zebrafish model of type 1 diabetes, we identified inhibitors of non-canonical IκB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε), as enhancers...

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Publicado en:Sci Rep
Autores principales: Xu, Jin, Jia, Yun-Fang, Tapadar, Subhasish, Weaver, Jessica D., Raji, Idris O., Pithadia, Deeti J., Javeed, Naureen, García, Andrés J., Choi, Doo-Sup, Matveyenko, Aleksey V., Oyelere, Adegboyega K., Shin, Chong Hyun
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197228/
https://ncbi.nlm.nih.gov/pubmed/30349097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33875-0
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