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Grapefruit juice, lyophilized grapefruit juice, and powdered whole grapefruit inhibit cytochrome P450 mediated triazolam hydroxylation by beagle dog liver microsomes
Coadministration of grapefruit juice has been proposed to enhance the systemic availability and decrease the required dose of drugs such as cyclosporine that are extensively metabolized in the intestine and liver. Although grapefruit juice inhibits human cytochrome P450 (CYP) 3A, effects on dog CYP...
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| Publicado no: | J Vet Pharmacol Ther |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6195767/ https://ncbi.nlm.nih.gov/pubmed/20444044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2885.2009.01124.x |
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