Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS

Several peptides in clinical use are derived from non-ribosomal peptide synthetases (NRPS). In these systems multiple NRPS subunits interact with each other in a specific linear order mediated by specific docking domains (DDs), whose structures are not known yet, to synthesize well-defined peptide p...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Hacker, Carolin, Cai, Xiaofeng, Kegler, Carsten, Zhao, Lei, Weickhmann, A. Katharina, Wurm, Jan Philip, Bode, Helge B., Wöhnert, Jens
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195595/
https://ncbi.nlm.nih.gov/pubmed/30341296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06712-1
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