Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of liver-specific gene expression with potent tumor suppressor activity, yet many liver tumors express HNF4α. This study reveals that P1-HNF4α, the predominant isoform expressed in the adult liver, inhibits expression of tumor promoting...

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Publicat a:Nat Commun
Autors principals: Fekry, Baharan, Ribas-Latre, Aleix, Baumgartner, Corrine, Deans, Jonathan R., Kwok, Christopher, Patel, Pooja, Fu, Loning, Berdeaux, Rebecca, Sun, Kai, Kolonin, Mikhail G., Wang, Sidney H., Yoo, Seung-Hee, Sladek, Frances M., Eckel-Mahan, Kristin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195513/
https://ncbi.nlm.nih.gov/pubmed/30341289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06648-6
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