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In vivo chloride concentrations surge to proteotoxic levels during acid stress

To successfully colonize the intestine, bacteria must survive passage through the stomach. The permeability of the outer membrane renders the periplasm of Gram-negative bacteria vulnerable to stomach acid, which inactivates proteins. Here we report that the semipermeable nature of the outer membrane...

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Foilsithe in:Nat Chem Biol
Main Authors: Stull, Frederick, Hipp, Hannah, Stockbridge, Randy B., Bardwell, James C. A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193267/
https://ncbi.nlm.nih.gov/pubmed/30323217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0143-z
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