Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), inducing a senescence-associated secretory phenotype (SASP) characterized by chronic secretion of diverse soluble factors. Here we report serine protease inhibitor Ka...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Chen, Fei, Long, Qilai, Fu, Da, Zhu, Dexiang, Ji, Yan, Han, Liu, Zhang, Boyi, Xu, Qixia, Liu, Bingjie, Li, Yan, Wu, Shanshan, Yang, Chen, Qian, Min, Xu, Jianmin, Liu, Suling, Cao, Liu, Chin, Y. Eugene, Lam, Eric W.-F., Coppé, Jean-Philippe, Sun, Yu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193001/
https://ncbi.nlm.nih.gov/pubmed/30333494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06860-4
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