Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

AIMS: Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathological mechanisms of DCM are unclear mainly due to num...

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Bibliographic Details
Published in:PLoS One
Main Authors: Schick, Revital, Mekies, Lucy N., Shemer, Yuval, Eisen, Binyamin, Hallas, Tova, Ben Jehuda, Ronen, Ben-Ari, Meital, Szantai, Agnes, Willi, Lubna, Shulman, Rita, Gramlich, Michael, Pane, Luna Simona, My, Ilaria, Freimark, Dov, Murgia, Marta, Santamaria, Gianluca, Gherghiceanu, Mihaela, Arad, Michael, Moretti, Alessandra, Binah, Ofer
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192629/
https://ncbi.nlm.nih.gov/pubmed/30332462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205719
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