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Structural basis of pyrrole polymerization in human porphobilinogen deaminase
Human porphobilinogen deaminase (PBGD), the third enzyme in the heme pathway, catalyzes four times a single reaction to convert porphobilinogen into hydroxymethylbilane. Remarkably, PBGD employs a single active site during the process, with a distinct yet chemically equivalent bond formed each time....
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| Publicado no: | Biochim Biophys Acta Gen Subj |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6192514/ https://ncbi.nlm.nih.gov/pubmed/29908816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2018.06.013 |
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