Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord

Intrathecal administration of brain derived neurotrophic factor (BDNF) induces long-term potentiation (LTP) and generates long-lasting central sensitization in spinal cord thus mimicking chronic pain, but the relevance of these observations to chronic pain mechanisms is uncertain. Since C-fiber acti...

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Publicat a:Front Pharmacol
Autors principals: Retamal, Jeffri, Reyes, Andrea, Ramirez, Paulina, Bravo, David, Hernandez, Alejandro, Pelissier, Teresa, Villanueva, Luis, Constandil, Luis
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191473/
https://ncbi.nlm.nih.gov/pubmed/30364099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01143
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