A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

Mechanisms that limit thrombosis are poorly defined. One of the few known endogenous platelet inhibitors is nitric oxide (NO). NO activates NO sensitive guanylyl cyclase (NO-GC) in platelets, resulting in an increase of cyclic guanosine monophosphate (cGMP). Here we show, using cGMP sensor mice to s...

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Udgivet i:Nat Commun
Main Authors: Wen, Lai, Feil, Susanne, Wolters, Markus, Thunemann, Martin, Regler, Frank, Schmidt, Kjestine, Friebe, Andreas, Olbrich, Marcus, Langer, Harald, Gawaz, Meinrad, de Wit, Cor, Feil, Robert
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191445/
https://ncbi.nlm.nih.gov/pubmed/30327468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06638-8
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