Trio-Based Deep Sequencing Reveals a Low Incidence of Off-Target Mutations in the Offspring of Genetically Edited Goats

Unintended off-target mutations induced by CRISPR/Cas9 nucleases may result in unwanted consequences, which will impede the efficient applicability of this technology for genetic improvement. We have recently edited the goat genome through CRISPR/Cas9 by targeting MSTN and FGF5, which increased musc...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Li, Chao, Zhou, Shiwei, Li, Yan, Li, Guanwei, Ding, Yige, Li, Lan, Liu, Jing, Qu, Lei, Sonstegard, Tad, Huang, Xingxu, Jiang, Yu, Chen, Yulin, Petersen, Bjoern, Wang, Xiaolong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190895/
https://ncbi.nlm.nih.gov/pubmed/30356875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00449
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