Severe toxicity to capecitabine due to a new variant at a donor splicing site in the dihydropyrimidine dehydrogenase (DPYD) gene

Severe, life-threatening adverse reactions to capecitabine sometimes occur in the treatment of solid tumors. Screening for dihydropyrimidine dehydrogenase (DPYD) deficiency is encouraged before start of treatment, but the genetic variants that are commonly analyzed often fail to explain toxicities s...

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Detalhes bibliográficos
Publicado no:Cancer Manag Res
Main Authors: García-González, Xandra, López-Tarruella, Sara, García, María Isabel, González-Haba, Eva, Blanco, Carolina, Salvador-Martin, Sara, Jerez, Yolanda, Thomas, Fabienne, Jarama, María, Sáez, María Sanjurjo, Martín, Miguel, López-Fernández, Luis Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190816/
https://ncbi.nlm.nih.gov/pubmed/30349384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S174470
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