Co-regulatory networks of human serum proteins link genetics to disease

Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correl...

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Udgivet i:Science
Main Authors: Emilsson, Valur, Ilkov, Marjan, Lamb, John R., Finkel, Nancy, Gudmundsson, Elias F., Pitts, Rebecca, Hoover, Heather, Gudmundsdottir, Valborg, Horman, Shane R., Aspelund, Thor, Shu, Le, Trifonov, Vladimir, Sigurdsson, Sigurdur, Manolescu, Andrei, Zhu, Jun, Olafsson, Örn, Jakobsdottir, Johanna, Lesley, Scott A., To, Jeremy, Zhang, Jia, Harris, Tamara B., Launer, Lenore J., Zhang, Bin, Eiriksdottir, Gudny, Yang, Xia, Orth, Anthony P., Jennings, Lori L., Gudnason, Vilmundur
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190714/
https://ncbi.nlm.nih.gov/pubmed/30072576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaq1327
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