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Sequence Determinants of DNA Binding by the Hematopoietic Helix-Loop-Helix Transcription Factor TAL1: Importance of Sequences Flanking the E-Box Core

TAL1 is a helix-loop-helix transcription factor that is essential for hematopoiesis. In vitro DNA binding site selection experiments have previously identified the preferred binding site for TAL1 heterodimers as AACAGATGGT. TAL1 homodimers do not bind DNA with significant affinity. A subset of other...

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Detalhes bibliográficos
Publicado no:Gene Expr
Main Authors: Gould, Karen A., Bresnick, Emery H.
Formato: Artigo
Idioma:Inglês
Publicado em: Cognizant Communication Corporation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190197/
https://ncbi.nlm.nih.gov/pubmed/9699481
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