Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis through the AKT/GSK-3β/β-Catenin Signaling Pathway

Sirtuin 2 (Sirt2), a NAD(+)-dependent protein deacetylase, is overexpressed in many hepatocellular carcinomas (HCCs) and can deacetylate many proteins, including tubulins and AKT, prior to AKT activation. Here, we found that endogenous Sirt2 was upregulated in wild-type hepatitis B virus (HBV WT)-re...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Piracha, Zahra Zahid, Kwon, Hyeonjoong, Saeed, Umar, Kim, Jumi, Jung, Jaesung, Chwae, Yong-Joon, Park, Sun, Shin, Ho-Joon, Kim, Kyongmin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2018
Onderwerpen:
Virus-Cell Interactions
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189494/
https://ncbi.nlm.nih.gov/pubmed/30111572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00955-18
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