Hepatocyte expression and prognostic importance of senescence marker p21 in liver histopathology samples from dogs with chronic hepatitis

BACKGROUND: Chronic hepatitis (CH) occurs commonly in dogs but is associated with a variable and largely unpredictable prognosis. p21, a cell‐cycle inhibitor and marker of cellular senescence, is upregulated in human liver disease and is a better prognostic marker than histological or clinical scori...

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Udgivet i:J Vet Intern Med
Main Authors: Kortum, Andre J., Cloup, Emilie A., Williams, Tim L., Constantino‐Casas, Fernendo, Watson, Penny J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2018
Fag:
SMALL ANIMAL
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189352/
https://ncbi.nlm.nih.gov/pubmed/30133945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jvim.15238
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