Sex-Dependent Effects of Environmental Enrichment on Spatial Memory and Brain-Derived Neurotrophic Factor (BDNF) Signaling in a Developmental “Two-Hit” Mouse Model Combining BDNF Haploinsufficiency and Chronic Glucocorticoid Stimulation

Neurodevelopmental disorders are thought to be caused by a combination of adverse genetic and environmental insults. The “two-hit” hypothesis suggests that an early first “hit” primes the developing brain to be vulnerable to a second “hit” during adolescence which triggers behavioral dysfunction. We...

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Detalhes bibliográficos
Publicado no:Front Behav Neurosci
Main Authors: Grech, Adrienne M., Ratnayake, Udani, Hannan, Anthony J., van den Buuse, Maarten, Hill, Rachel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189322/
https://ncbi.nlm.nih.gov/pubmed/30356704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2018.00227
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