Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules

Common CCR5-∆32 and HLA alleles only explain a minority of the HIV long-term non-progressor (LTNP) and elite controller (EC) phenotypes. To identify rare genetic variants contributing to the slow disease progression phenotypes, we performed whole exome sequencing (WES) on seven LTNPs and four ECs. H...

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Publicat a:Sci Rep
Autors principals: Nissen, Sara Konstantin, Christiansen, Mette, Helleberg, Marie, Kjær, Kathrine, Jørgensen, Sofie Eg, Gerstoft, Jan, Katzenstein, Terese L, Benfield, Thomas, Kronborg, Gitte, Larsen, Carsten S, Laursen, Alex, Pedersen, Gitte, Jakobsen, Martin R, Tolstrup, Martin, Mogensen, Trine H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189090/
https://ncbi.nlm.nih.gov/pubmed/30323326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33481-0
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