HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry

The HIV Tat protein competes with the 7SK:HEXIM interaction to hijack pTEFb from 7SK snRNP and recruit it to the TAR motif on stalled viral transcripts. Here we solve structures of 7SK stemloop-1 and TAR in complex with Tat’s RNA binding domain (RBD) to gain insights into this process. We find that...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pham, Vincent V., Salguero, Carolina, Khan, Shamsun Nahar, Meagher, Jennifer L., Brown, W. Clay, Humbert, Nicolas, de Rocquigny, Hugues, Smith, Janet L., D’Souza, Victoria M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189040/
https://ncbi.nlm.nih.gov/pubmed/30323330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06591-6
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