Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism

Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ždralević, Maša, Brand, Almut, Di Ianni, Lorenza, Dettmer, Katja, Reinders, Jörg, Singer, Katrin, Peter, Katrin, Schnell, Annette, Bruss, Christina, Decking, Sonja-Maria, Koehl, Gudrun, Felipe-Abrio, Blanca, Durivault, Jérôme, Bayer, Pascale, Evangelista, Marie, O'Brien, Thomas, Oefner, Peter J., Renner, Kathrin, Pouysségur, Jacques, Kreutz, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187639/
https://ncbi.nlm.nih.gov/pubmed/30158244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004180
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