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Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry

[Image: see text] Target-directed dynamic combinatorial chemistry (DCC) has emerged as a strategy for the identification of inhibitors of relevant therapeutic targets. In this contribution, we use this strategy for the identification of a high-affinity binder of a parasite target, the Trypanosoma cr...

詳細記述

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: García, Paula, Alonso, Victoria L., Serra, Esteban, Escalante, Andrea M., Furlan, Ricardo L. E.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2018
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187412/
https://ncbi.nlm.nih.gov/pubmed/30344907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00247
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