Human Endogenous Retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

HERV-K HML-2 (HK2) has been proliferating in the germ line of humans at least as recently as 250,000 years ago, with some integrations that remain polymorphic in the modern human population. One of the solitary HK2 LTR polymorphic integrations lies between exons 17 and 18 of RASGRF2, a gene that aff...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Karamitros, Timokratis, Hurst, Tara, Marchi, Emanuele, Karamichali, Eirini, Georgopoulou, Urania, Mentis, Andreas, Riepsaame, Joey, Lin, Audrey, Paraskevis, Dimitrios, Hatzakis, Angelos, McLauchlan, John, Katzourakis, Aris, Magiorkinis, Gkikas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187174/
https://ncbi.nlm.nih.gov/pubmed/30249655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811940115
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