EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

Inv(3q26) and t(3:3)(q21;q26) are specific to poor-prognosis myeloid malignancies, and result in marked overexpression of EVI1, a zinc-finger transcription factor and myeloid-specific oncoprotein. Despite extensive study, the mechanism by which EVI1 contributes to myeloid malignancy remains unclear....

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Ayoub, Edward, Wilson, Michael P., McGrath, Kathleen E., Li, Allison J., Frisch, Benjamin J., Palis, James, Calvi, Laura M., Zhang, Yi, Perkins, Archibald S.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185954/
https://ncbi.nlm.nih.gov/pubmed/30315161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06208-y
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