ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

Dysfunction of the noradrenergic (NE) neurons is implicated in the pathogenesis of bipolar disorder (BPD). ErbB4 is highly expressed in NE neurons, and its genetic variation has been linked to BPD; however, how ErbB4 regulates NE neuronal function and contributes to BPD pathogenesis is unclear. Here...

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發表在:eLife
Main Authors: Cao, Shu-Xia, Zhang, Ying, Hu, Xing-Yue, Hong, Bin, Sun, Peng, He, Hai-Yang, Geng, Hong-Yan, Bao, Ai-Min, Duan, Shu-Min, Yang, Jian-Ming, Gao, Tian-Ming, Lian, Hong, Li, Xiao-Ming
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2018
主題:
Neuroscience
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185106/
https://ncbi.nlm.nih.gov/pubmed/30179154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39907
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